In order to investigate the effect of Alismatis Lhizoma on hyperlipidemia, experimental studies were performed on hyperlipidemia rats. Hyperlipidemia model (controll group) was induced by 1% cholesterol fed-diet for 8 weeks. Sample I group fed with 1% cholesterol and 4% Alismatis Lhizoma diet for 8 weeks. Sample II group fed with 1% cholesterol and 8% Alismatis Lhizoma diet for 8 weeks. The contents of serum total cholesterol, triglyceride, free fatty acid, phospholipid, HDL-cholesterol and LDL-cholesterol were measured, and fat accumulation in liver and the change of elastic and collagenous fiber in aortic wall were observed.
The results were summurized as follows ;
1. The content of total cholesterol in the serum compared with control group tended to be decreased in sample group, and then sample I group showed a significant value.
2. The content of triglyceride in the serum compared with control group tended to be decreased in sample group, and then sample I group showed a significant value.
3. The content of free fat acid in the serum compared with control group tended to be decreased in sample group, but did not show a significance.
4. The content of phospholipid in the serum compared with control group tended to be decreased in sample group, and then sample I group showed a significant value.
5. The content of HDL-cholesterol in the serum compared with control group tended to be increased in sample group, and then sample II group showed a significant value.
6. The content of LDL-cholesterol in the serum compared with control group tended to be decreased in sample group, and then sample I group showed a significant value.
7. The lipophagy in liver compared with control group tended to be repressed in sample group.
8. The change of elastic and collagenous fiber lesion in tunica media of aortic wall, compared with control group tended to be repressed in sample group. According to the above results, it is assumed that Alismatis Lhizoma has a valid effect on hyperlipidemia. And yet, it needs to make further researches that sample I group showed more significant value than sample II group.
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